Efficacy in adults with Huntington’s disease chorea

SELECT EFFICACY ENDPOINT:

12-week
TMC reduction

2-year
TMC reduction

2-year
GI-C/PGI-C

12-week TMC reduction

INGREZZA provides rapid and sustained HD chorea control1,2

Reductions seen as early as Week 2 and at all study visits

Mean change in Total Maximal Chorea score over time1,2

Mean change in Total Maximal Chorea score over time, chart Mean change in Total Maximal Chorea score over time, chart
Mean change in Total Maximal Chorea score over time, chart

aP<0.0001.

Baseline is the average of screening and Day –1 assessments; end of treatment is the average of Week 10 and Week 12 assessments.

TMC, Total Maximal Chorea; SEM, standard error of mean; LS mean, least squares mean.

aP<0.0001.

Baseline is the average of screening and Day –1 assessments; end of treatment is the average of Week 10 and Week 12 assessments.

TMC, Total Maximal Chorea; SEM, standard error of mean; LS mean, least squares mean.

HD chorea control was sustained long-term3

Reductions in TMC score sustained through 2 years

Mean change in Total Maximal Chorea score over time in interim analysis of KINECT-HD2, a long-term, open-label study3

Mean Change from Baseline vs Maintenance period 80 mg once daily, Total Maximal Chorea
Mean Change from Baseline vs Maintenance period 80 mg once daily, Total Maximal Chorea
Percent improvement in TMC Score, graph

THE ONLY VMAT2 INHIBITOR STUDIED IN PATIENTS WITH HD CHOREA TAKING ANTIPSYCHOTICS3

Physicians and patients see high rates of success, long-term

Percentage of physicians and patients rating overall symptoms of chorea as “very much improved” or “much improved” with INGREZZA at 2 years3,*

74% for Clinical global impression of Change (CGI-C)
74% for Clinical global impression of Change (CGI-C)
76% for Patient Global Impression of Change (PGI-C)
76% for Patient Global Impression of Change (PGI-C)
*

Data from interim analysis of KINECT-HD2, a long-term, open-label study.

Watch expert perspective videos on INGREZZA

Featuring Steven Lo, MD; Lawrence Elmer, MD, PhD; Bisena Bulica, DO

These videos were sponsored and developed by Neurocrine Biosciences.
The speakers are paid consultants of Neurocrine Biosciences.

About the KINECT-HD pivotal study

Lawrence Elmer, MD, PhD; Steven Lo, MD; and Bisena Bulica, DO, discuss the KINECT-HD pivotal study

Efficacy and safety of INGREZZA in patients
with HD chorea

Lawrence Elmer, MD, PhD, and Steven Lo, MD, discuss INGREZZA in patients with HD chorea

THERAPEUTIC DOSE FROM DAY 1

The only VMAT2 inhibitor that offers an effective starting dosage you can adjust based on response and tolerability1

EXPLORE DOSING

SEE PATIENT CASES
FROM KINECT-HD

View videos of clinical trial patients with HD chorea treated with INGREZZA

WATCH CASE VIDEOS

INGREZZA CLINICAL
SAFETY DATA

INGREZZA was studied across a broad range of patients with HD chorea

VIEW SAFETY PROFILE

REFERENCES:

  1. INGREZZA [package insert]. San Diego, CA: Neurocrine Biosciences, Inc.
  2. Stimming EF, Claassen DO, Kayson E, et al. Safety and efficacy of valbenazine for the treatment of chorea associated with Huntington’s disease (KINECT-HD): a phase 3, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2023;22(6):494-504.
  3. Data on file. Neurocrine Biosciences, Inc.
  4. Unified Huntington’s Disease Rating Scale: reliability and consistency. Huntington Study Group. Mov Disord. 1996;11(2):136-142.
  5. Guy W. ECDEU Assessment Manual for Psychopharmacology. Revised 1976. Rockville, MD: National Institute of Mental Health; 1976.
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Important Safety Information

Depression and Suicidality in Patients with Huntington’s Disease: VMAT2 inhibitors, including INGREZZA, can increase the risk of depression and suicidal thoughts and

Important Information

INDICATION & USAGE

INGREZZA® (valbenazine) capsules and INGREZZA® SPRINKLE (valbenazine) capsules are indicated in adults for the treatment of tardive dyskinesia and for the treatment of chorea associated with Huntington’s disease.

IMPORTANT SAFETY INFORMATION

Depression and Suicidality in Patients with Huntington’s Disease: VMAT2 inhibitors, including INGREZZA and INGREZZA SPRINKLE, can increase the risk of depression and suicidal thoughts and behavior (suicidality) in patients with Huntington’s disease. Balance the risks of depression and suicidality with the clinical need for treatment of chorea. Closely monitor patients for the emergence or worsening of depression, suicidal ideation, or unusual changes in behavior. Inform patients, their caregivers, and families of the risk of depression and suicidal ideation and behavior and instruct them to report behaviors of concern promptly to the treating physician. Exercise caution when treating patients with a history of depression or prior suicide attempts or ideation, which are increased in frequency in patients with Huntington’s disease.